Demi Moore continued her strong awards season run for “The Substance” by taking home the SAG Award for outstanding performance by a female actor in a lead role. The victory was Moore’s third among the major Oscar precursor ceremonies.

The Substance’s Demi Moore just won Outstanding Performance by a Female Actor in a Leading Role at the 2025 SAG Awards—and added more momentum to her Oscar campaign. The star took the stage and gave an acceptance speech centered on her decades-long journey as an actor and how her fellow SAG-AFTRA members shaped her life.

Demi Moore won Best Actress for The Substance at Sunday’s Screen Actors Guild Awards, adding another wrinkle to the Oscar race. Moore, who was in first place in the Gold Derby odds, beat Mikey Madison (Anora),