Pope Leo XIV holds his first general audience in St. Peter’s Square on Wednesday, issuing an appeal for Gaza, which he calls an “increasingly worrying and painful” situation, harming children, elderly, and the sick in particular.

The Vatican has a deep history of conflict mediation, with varying degrees of success. An effort by the pope to end the war in Ukraine would face long odds.

Jumping straight into the geopolitical fray, the words of the U.S.-born pontiff are meant to single out Vladimir Putin — a notable difference with Pope Francis. The timing may also be just right to help his fellow American,