The Guardians reached the quarter mark of the 2025 season on Sunday, in a 3-0 loss to the Phillies at Progressive Field in the rubber match of a three-game series.

Preview the May 10 matchup between the Philadelphia Phillies and Cleveland Guardians with odds over/under, game spread, betting lines and more.

SportsLine's proven model has simulated the Philadelphia Phillies vs. Cleveland Guardians 10,000 times and released its MLB best bets

The Philadelphia Phillies take on the Cleveland Guardians in the third and decisive game of their interleague series on Sunday Night Baseball.

Our MLB prop picks don't see Zack Wheeler having the easiest of times on the mound tonight due to multiple circumstances out of his control. That should work to Jose Ramirez's advantage on Sunday Night Baseball.

It’s time to continue our MLB odds series with a Phillies-Guardians prediction and pick. Find out how to watch Phillies-Guardians. The Philadelphia Phillies have reason to be optimistic about their season.

See all the player props bets with current odds for the MLB matchup between the Philadelphia Phillies and Guardians on }{ day_of_week model.date }},

The consecutive losses represent a concerning pattern in an increasingly tight AL Central race. Detroit and Kansas City are locked in a three-way battle with Cleveland, while Minnesota has surged, winning eight straight games to move above .500.

Guardians face Brewers with a big matchup between Priester and Allen. Meanwhile, doubleheaders are scheduled for Phillies, Cardinals, and more.

Which brings us to our question of the day: which is your favorite interleague matchup to watch when the Phillies are involved? Maybe you enjoy the AL East teams that are considered the Phillies’ “rivals”. Maybe you like the novelty of seeing teams from the AL West. There has to be one matchup that always catches your fancy.

Preview the May 11 matchup between the Philadelphia Phillies and Cleveland Guardians with recent trends, how to watch, livestream info, and more.