Losing key players to injury during the NBA playoffs is not uncommon; it happens every year. But it still hurts each time someone goes down.

The Philadelphia 76ers didn't qualify for the 2025 NBA playoffs, largely due to the unavailability of their star players as Tyrese Maxey, Paul George and Joel Embiid struggled to stay healthy in the 2024-25 season. This is the first time the Sixers missed the playoffs since 2017, snapping their streak of seven straight postseason appearances.

A handful of injuries have changed the course of NBA history — here are the most devastating to occur during the postseason.

Dan Patrick discusses how injuries to star players like Jayson Tatum and Steph Curry have changed the landscape of the 2025 NBA Playoffs.

With less than 30 seconds left in regulation, Gordon hit a 3 to tie the Denver Nuggets with the Oklahoma Thunder and send Game 3 into OT.

Golden State Warriors star Stephen Curry was officially ruled out for Wednesday's Game 5 of his team's second-round series against the Minnesota Timberwolves because of his hamstring injury.

What to know: Cleveland is in a world of hurt. It played without star shooting guard Donovan Mitchell (ankle) for the second half of Sunday's Game 4, a blowout defeat. Indiana plastered the Cavs, and was up 80-39 at halftime. The top-seed in the East is now down 3-1, heading back home for Game 5.