Tepetlixpa is a municipality in the State of Mexico in Mexico. The municipality covers an area of 46.68 km² and borders on the state of …Tepetlixpa is a municipality in the State of Mexico in Mexico. The municipality covers an area of 46.68 km² and borders on the state of Morelos. In 2000, the municipality had a total population of 16,871. By 2020, the figure had risen to 20,500.